Levofloxacin is an antibiotic used to treat bacterial infections.
Levofloxacin is a third generation broad-spectrum fluoroquinolone.
It is one of the isomers of Ofloxacin.
Levofloxacin is more effective against gram-positive, gram-negative and aerobic bacteria.
It does not work well against anaerobic bacteria.
Levofloxacin Tablet Uses
1) Pneumonia
2) Urinary Tract Infection (UTI)
3) Skin & Soft Tissue Infections (SSTI)
4) Bronchitis
5) Sinusitis
6) Infection in the lungs
7) Infection in the upper respiratory tract (URTI)
8) Other bacterial infections
9) Diabetic Foot Infection
10) Prostatitis
11) Kidney Infection
12) Anthrax
13) Plague
Mode of Action of Levofloxacin
Levofloxacin acts on bacterial topoisomerase. Levofloxacin acts on topoisomerase 2 and topoisomerase 4.
Topoisomerase 2 and topoisomerase 4 are enzymes that are important for bacterial DNA growth, replication, transcription and repair.
Levofloxacin binds to bacterial topoisomerase 2 and topoisomerase 4 and because this supercoiling does not occur in the bacterial DNA and the bacterial growth (replication) stops and the bacteria dies.
Levofloxacin also inhibits several other important activities inside bacteria.
Levofloxacin weakens bacterial cell membranes. For this reason, the bacterial cell is unable to maintain its shape and is destroyed.
Pharmacokinetics of Levofloxacin
The bio availability of levofloxacin is 99%.
This means that Levofloxacin is completely absorbed by our body and reaches its peak concentration (T-max) in the blood within 1.5 hours.
Levofloxacin is metabolized in the liver and 87% is excreted in the urine. Half of levofloxacin excreted by our body in 8 hours.
Dosage of Levofloxacin Tablets
A single dose of levofloxacin, i.e. once daily, is used. Depending on the infection, 500 mg to 750 mg is given for 3 to 14 days.
In some infections, the drug is also administered continuously for 28 days.
In children, levofloxacin was administered in once-daily doses ranging from 8 mg/kg to 20 mg/kg.
Levofloxacin should not be taken more than 750 mg per day.
Side Effects of Levofloxacin Tablets
1) Diarrhea and abdominal pain
2) Vomiting or feeling sick
3) Loss of appetite and indigestion
4) Headache and dizziness
5) Insomnia and confusion
6) Itching
7) Changes in taste
8) Increased liver enzymes
9) Swelling and pain in muscles and joints
10) Irregular heartbeat
Who Should Not Take Levofloxacin
1) Liver and kidney patients
2) Women who are breastfeeding
3) Patient has irregular heartbeat
4) Patients with depression
5) Pregnant women
6) People with joint problems
7) Patients with myasthenia gravis
8) Tendon disorder patient
Which Medicine Should not be Given With Levofloxacin
1) Cisapride
2) Dronedarone
3) Pimozide
4) Thioridazine
5) Fezolinetant
There are some other medicines also for which alternative medicine should be given like
Adagrasib, Aluminum hydroxide, Amiodarone, Amisulpride, Anagrelide, Apomorphine, Arsenic trioxide, Artemether, Asenapine, Asenapine transdermal, BCG vaccine live, Buprenorphine, Buprenorphine buccal, Buprenorphine subdermal implant, Buprenorphine, long-acting injection, Carbonyl iron, Ceritinib, Cholera vaccine, Desflurane, Didanosine, Disopyramide, Encorafenib, Entrectinib, Eribulin, Ferric maltol, Ferrous fumarate, Ferrous gluconate, Ferrous sulfate, Fexinidazole, Glasdegib hydroxychloroquine sulfate, Ibutilide, Indapamide, Inotuzumab, Iron dextran complex, Iron sucrose, Isoflurane, Ivosidenib, Lefamulin, Macimorelin, Methyl aminolevulinate, Microbiota oral, Mobocertinib, Ondansetron, Oxaliplatin, Panobinostat, Pentamidine, Pimozide, Pitolisant, Polysaccharide iron, Procainamide, Quinidine, Ribociclib, Rose hips, Saquinavir, Selinexor, Sevoflurane, Siponimod, Sodium bicarbonate, Sodium citrate/citric acid, Sotalol, Strontium ranelate, Tetrabenazine, Toremifene, Tretinoin, Tretinoin topical, Trilaciclib, Typhoid vaccine live, Umeclidinium, Bromide/vilanterol inhaled, Vandetanib, Vemurafenib, Vilanterol/fluticasone furoate inhaled.
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