Dolo 650 mg is an analgesic and antipyretic drug used to reduce pain and fever.
Dolo 650 contains Paracetamol 650 mg and is manufactured by Micro Labs. Paracetamol is also known as Acetaminophen.
Dolo 650mg is safer than any other painkiller, especially NSAIDs.
Dolo 650 Tablet Uses
1) Fever
2) Pain in any part of the body
3) Migraine
4) Common cold
5) Sore Throat
 Mode of Action of Dolo 650 Tablet
Dolo acts on the Central Nervous System (CNS) where it works by inhibiting an enzyme called prostaglandin.
It blocks the Cox-2 enzyme in our body. The COX 2 enzyme gives the signal to make prostaglandin.
Prostaglandins send pain signals to our brain due to which we feel pain.
Paracetamol prevents or reduces the production of prostaglandins, due to which we do not feel pain.
Paracetamol works by increasing the activity of Cannabinoid Receptors, especially CB-1 receptors in our CNS.
Because of this, the analgesic effect (pain reliever) comes.
Paracetamol prevents the release of an enzyme called Pyrogen by our brain.
Pyrogen itself works to increase the body temperature.
When pyrogen is not released, our body temperature will not be able to rise.
Dolo 650 Side Effects
Dolo (Paracetamol) is considered a safe medicine and does not have any side effects.
But in some patients, its continuous and prolonged use may cause side effects.
1) Decreased hemoglobin
2) Bleeding in the intestines
3) Stomach ulcer
4) Damage to the liver and kidney
5) Increase in blood pressure
6) Increase in heart rate
Recommended Dosage of Dolo 650 Per Day
Dolo is considered to be the safest drug and depending on the symptoms a maximum of 4 grams of Dolo can be taken in a day.
Dolo 650 mg can be given to the patient every 4 to 6 hours.
In children up to 6 months, 60 mg of Dolo can be given every 4 to 6 hours.
In children from 6 months to 1 year, 120 mg of Dolo can be given every 4 to 6 hours.
In children from 1 year to 3 years, 180 mg of Dolo can be given every 4 to 6 hours.
In children from 3 years to 5 years, 240 mg of Dolo can be given every 4 to 6 hours.
In children from 5 years to 7 years, 250 mg of Dolo can be given every 4 to 6 hours.
In children from 7 years to 9 years, 375 mg of Dolo can be given every 4 to 6 hours.
In children from 9 years to 11 years, 500 mg of Dolo can be given every 4 to 6 hours.
In children from 11 years to 15 years, 500 mg to 750 mg of Dolo can be given every 4 to 6 hours.
For persons above 16 years, 500 mg to 1 gram can be given every 4 to 6 hours.
Keep in mind that more than 4 g dose of Dolo should not be given in a day. The dose can be given according to 15 mg/kg in children.
Is Dolo Safe in Pregnancy and Breastfeeding Women
Yes, Dolo is considered one of the safest medicines and can be given to pregnant women and lactating women.
When Should You not Take Dolo 650
1) If you are allergic to paracetamol
2) You have taken any medicine that already contains paracetamol
3) If you have any liver or kidney disease
4) Drinking alcohol in excess
5) Dose needs to be adjusted for underweight people
How Long Does it Take for Dolo 650 to Work
Dolo gets absorbed immediately after going into the body.
If you take Dolo empty stomach then it will start showing its effect in 30 minutes and if you take Dolo after eating something then Dolo starts showing its effect in 90 minutes.
Paracetamol is a dose-dependent drug, which means that the higher the dose, the higher the absorption of the drug in our body.
For example, on taking 500 mg of Dolo, its bio availability is 63% while on taking 1000 mg, its bio availability increases to 89%.
What Drug Interactions are There for Dolo 650
Dolo can interact with some other medicines to increase or decrease its effect.
In such a situation, you should take medicines only after consulting a doctor like
Ketoconazole, Levoketoconazole, Phenobarbital, Primidone, Isoniazid, Ranitidine, Nizatidine, Cisapride, Blood Thinners, Carbamazepine, Colestyramine, Imatinib, Busulfan, Lixisenatide, Metoclopramide, Phenobarbital, Phenytoin.
What Happens if You Take Too Much Dolo
Dolo can show serious side effects if taken in excess of the recommended dose. As
1) Abdominal pain
2) Vomiting or feeling like vomiting
3) Liver problem
4) Seizures
5) Coma
6) Death
Although this happens in rare cases. In case of overdose contact your doctor.
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