The Science Behind Clindamycin: How it Works to Fight Bacterial Infections

Clindamycin is a strong antibiotic. It is given to treat serious infections caused by bacteria. 

Clindamycin is a lincosamide antibiotic. It prevents the growth of bacteria. 

In most cases, it is given when penicillin (such as amoxicillin) does not work. 

Clindamycin is a pro drug and becomes active in our body. Clindamycin is available in three forms.

Clindamycin phosphate It is available in IV, inject-able or liquid form.

Clindamycin hydrochloride is available in tablet form.

Clindamycin nicotinamide is available as a cream. 


what is clindamycin used for


Clindamycin Tablet Uses

Clindamycin is given to cure bacterial infections like

1) Infection of the lungs or respiratory tract

2) Skin & soft tissue Infections

3) Infection of teeth & gums

4) Infections in bones or joints

5) Pelvic Inflammatory Disease (PID)

6) Bacterial Vaginosis

7) Sexually Transmitted Disease (STD)

8) Indra-abdominal infections
9) Septicemia

Mode of Action of Clindamycin Tablet 

Clindamycin enters bacterial cells and binds to the 50S sub unit of the bacterial ribosome.

Therefore, peptide bonds are not formed in amino acids and because peptide bonds are not formed, there is an obstacle in protein synthesis.

Due to lack of protein synthesis, bacteria do not receive protein for growth and other physiological functions and bacterial growth stops.

As a result, bacteria cannot grow or reproduce.

Clindamycin works best against gram-positive and anaerobic bacteria. 

It should be noted that clindamycin only inhibits protein synthesis in bacterial cells, it has no effect on human cells. 

Dosage of Clindamycin

The dose of clindamycin depends on the severity of the disease or infection.

Typically, clindamycin capsules are taken at a dose of 300 mg in the morning and 300 mg in the evening.

Depending on the condition of the infection, the doctor may increase or decrease the dose.

In children under one month, it is given at a dose of 20 mg/kg/day and divided into three parts.

In children from 1 month to 16 years, it is given at a dose of 40 mg/kg/day and divided into three parts. 

Side Effects of Clindamycin Tablet

1) Abdominal pain

2) Diarrhea

3) Change in the taste of the mouth

4) Fungal infection

5) Itching

6) Vomiting or Nausea

7) Decreased white blood cells

8) Difficulty in passing urine

9) Colitis 

What Cannot be Mixed With Clindamycin

Some drugs have serious consequences when combined with clindamycin. 

These medicines should not be taken with clindamycin as:

Atracurium, BCG vaccine live, Cholera vaccine, Cisatracurium, Microbiota oral, OnabotulinumtoxinA, Pancuronium, Rapacuronium, RimabotulinumtoxinB, Rocuronium, Succinylcholine, Typhoid vaccine live, Vecuronium

Can Pregnant and Lactating Women use Clindamycin

Clindamycin can be given to pregnant women during the first trimester, after first trimester consult your doctor. 

Clindamycin should not be used by lactating women.

It is found in milk between 0.5 mcg/mL and 3.8 mcg/mL, which is harmful to the baby. 

How Long Does it Take Clindamycin to Fully Work

Clindamycin can take 2-3 days to work. However, its effects only start 1 hour after taking it.

The bio availability of clindamycin is 90%. 10% of which is excreted in the urine and 4% in the feces.

Is Clindamycin Safe for Kidney and Liver Patients

Clindamycin should not be given to patients with liver and kidney disease without the advice of a doctor.

For such patients, the doctor adjusts the dosage. 




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